28 January 2013

Sodium Bicarbonate and Cancer

Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases

  1. Robert J. Gillies3
  1. 1Arizona Cancer Center, University of Arizona, Tucson, Arizona; 2Department of Pharmacology, Wayne State University, Detroit, Michigan; and 3H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida
  1. Requests for reprints:
    Robert J. Gillies, H. Lee Moffitt Cancer Center, SRB-2, 12302 Magnolia Drive, Tampa, FL 33612. Phone: 813-725-8355; Fax: 813-979-7265; E-mail: Robert.Gillies@moffitt.org.


The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and metastasis in vitro and in cells before tail vein injection in vivo. The present study investigates whether inhibition of this tumor acidity will reduce the incidence of in vivometastases. Here, we show that oral NaHCO3 selectively increased the pH of tumors and reduced the formation of spontaneous metastases in mouse models of metastatic breast cancer. This treatment regimen was shown to significantly increase the extracellular pH, but not the intracellular pH, of tumors by 31P magnetic resonance spectroscopy and the export of acid from growing tumors by fluorescence microscopy of tumors grown in window chambers. NaHCO3 therapy also reduced the rate of lymph node involvement, yet did not affect the levels of circulating tumor cells, suggesting that reduced organ metastases were not due to increased intravasation. In contrast, NaHCO3 therapy significantly reduced the formation of hepatic metastases following intrasplenic injection, suggesting that it did inhibit extravasation and colonization. In tail vein injections of alternative cancer models, bicarbonate had mixed results, inhibiting the formation of metastases from PC3M prostate cancer cells, but not those of B16 melanoma. Although the mechanism of this therapy is not known with certainty, low pH was shown to increase the release of active cathepsin B, an important matrix remodeling protease. [Cancer Res 2009;69(6):2260–8]

27 January 2013

Dana Ullman on Vaccines with References

Comments on the Vaccine Issue

The scientist to win the 1st Nobel Prize in Medicine was Emil Adolph von Behring for his discovery of the diphtheria vaccine. He later acknowledged that he was inspired to do his research by homeopathy.  Although vaccinations and homeopathy are both based on the "principle of similars," these two treatments are also quite different.  Homeopathic medicines are used in much smaller and safer doses; they are usually prescribed with much greater individualization, and homeopathic medicines are used to both treat AND prevent disease, not just prevent disease.  

I am personally not "against" vaccines.  To be against vaccines is akin to be against surgery.  Both treatments have their place in health care, but each treatment is inappropriate for everyone, and numerous factors need to be considered before accepting them as a reasonable strategy.  First and foremost, living in a free society, I strongly believe that no drugs should be mandatory.  Second, vaccines are not always safe, and they can cause chronic ailments in rare situations (but such situations are more common than is commonly realized).  Third, some acute infections, such as chicken pox and measles, may actually be important for children to experience as a way to augment and strengthen their emerging immune and defense systems (did you know that children who get measles tend to have a significantly lower incidence of respiratory allergies).  Finally, the primary reason that homeopathy became popular in the 19th century in Europe and in the USA was the result of the impressive results that homeopaths experienced in treating the various infectious disease epidemics that raged during that era.  In other words, homeopathic medicines can be effective in treating many modern infectious diseases.

The following books will help you better understand the place for homeopathic medicines in the prevention and treatment of modern infectious diseases, and some of these books will also teach you how to treat some of the symptoms that vaccinations can cause.

The Vaccine Guide: Risks and Benefits for Children and Adults. Randall Neustaedter, OMD.  This book describes the risks of getting vaccinating for each of the common vaccines as well as the risks of not getting vaccinated.  This book has 40 pages (!) of references and is a practical guidebook to parents.  

Vaccine Free: Prevention and Treatment of Infectious Contagious Disease with Homeopathy (2nd edition), Kate Birch, RSHom, CCH, CMT.  This comprehensive book describes how to use homeopathic medicines to prevent diseases and which homeopathic medicines to use to treat them.  

The Solution: Homeoprophylaxis--The Vaccine Alternative. Kate Birch, RSHom, CCH, CMT, and Cilla Whatcott, HD, CCH.  This book is a shorter and well-illustrated book that will teach you how to use homeopathic medicines to prevent various ailments...and does so with clear and easy protocols.  It also lists the common homeopathic medicines to treat infectious diseases, but it doesn't provide detailed information about each remedy in such treatment.

Vaccine Damaged Children: Treatment, Prevention, Reasons.  Isaac Golden, PhD. No single book can be a guide to the treatment of children who experience side effects from vaccines, but this book is a good first place to start.  Generally, one must go to a professional homeopath for individualized care, but this book will teach you why homeopathy should be considered in such instances.

The Complete Practitioner's Manual of Homoeoprophylaxis.  Isaac Golden, PhD.  This book provides detailed information on how to use homeopathic medicines to help prevent ailments. This book also reviews recent research, including a large study in Cuba, that shows significant reduction with the proper use of homeopathic medicines.

02 January 2013

Pulsed Electric Fields Kill Melanoma

The publisher's final edited version of this article is available at Biochem Biophys Res Commun
See other articles in PMC that cite the published article.

We have discovered a new, drug-free therapy for treating solid skin tumors. Pulsed electric fields greater than 20 kV/cm with rise times of 30 ns and durations of 300 ns penetrate into the interior of tumor cells and cause tumor cell nuclei to rapidly shrink and tumor blood flow to stop. Melanomas shrink by 90% within two weeks following a cumulative field exposure time of 120 μs. A second treatment at this time can result in complete remission. This new technique provides a highly localized targeting of tumor cells with only minor effects on overlying skin. Each pulse deposits 0.2 J and 100 pulses increase the temperature of the treated region by only 3 °C, ten degrees lower than the minimum temperature for hyperthermia effects.