Nutrient 'Cocktail' Delays Aging and Extends Life Span
By Susan Machado
An international coalition of researchers has proved in the laboratory that a comprehensive 'cocktail' of nutritional supplements significantly increased youthful life span.1
Since aging is a multifactorial process with overlapping causes, scientists formulated a 30-ingredient nutrient mixture with overlapping benefits designed to halt or slow the major causes of aging.
The nutrient mixture, developed by a team of life scientists led by Dr. C. David Rollo of McMaster University in Canada, targets five key mechanisms of aging.1-3 Researchers postulated that by slowing or reversing these five universal processes, they could slow or reverse the major factors of aging.
While this research was initially conducted on animals, every one of the 30 nutrients is already in human use as a supplement. All have established records of safety and effectiveness at promoting health and preventing specific disease processes. Many of the nutrients are already known to improve cognition, enhance mobility, slow aging, or extend life spans. Others have clear-cut beneficial effects on one or more of five key aging mechanisms, adding value to the combination as a whole.
The implications that this nutrient cocktail has on human longevity are profound.
Let's look now at these five fundamental causes of aging to understand the multiple ways that this nutrient mixture attacks them.
Targeting Five Key Mechanisms of Aging
Dr. Rollo's researchers recognized that, while aging is a complex phenomenon, most of its manifestations could be traced to a relatively small number of basic processes. Among these, there are five that account for most of the tissue, organ, and system dysfunction that produces chronic disease and untimely death. These five are well known to Life Extension® members: oxidative stress, inflammation, mitochondrial dysfunction, insulin resistance, and integrity of membranes.1-3
No single mechanism alone accounts for any one specific disease process. Instead, all five mechanisms interact with one another to produce both general aging and specific conditions that limit activity, cognitive function, and ultimately life span.
In developing a functional, multi-nutrient anti-aging formula, Dr. Rollo's group targeted the five key mechanisms of aging.
The scientists recognized that these specific mechanisms accounted for the vast majority of age-related, longevity-impairing conditions. In this way, the researchers cast a wide net to encompass as many disease states of aging as they could. Additionally, they chose laboratory mice to study the impact of the nutrients on aging because of the animals' short normal life span. This would help the researchers learn the most in the least amount of time. A mouse is considered 'old' by age 2 years, providing a convenient and realistic setting for the study of age-related conditions.3 A human study might have taken decades before they could draw meaningful conclusions.
Next, the researchers needed to establish markers of progressive aging. They wanted to know not only how long the animals lived, but also how well they functioned as they grew older. Most importantly, they needed measures that were equally applicable to both mice and to humans. Based on the work of others, Rollo's group decided that those criteria could be met by measuring how much the aging animals moved, and how their cognitive function changed with time. Read more ...
Conceived and designed the experiments: CK GH BE. Performed the experiments: CK BE GA. Analyzed the data: CK BE. Contributed reagents/materials/analysis tools: BE CK. Wrote the paper: CK GH BE. Maintained and transported honeybee colonies used for these experiments: KG.
Received August 18, 2011; Accepted November 23, 2011.
Populations of honey bees and other pollinators have declined worldwide in recent years. A variety of stressors have been implicated as potential causes, including agricultural pesticides. Neonicotinoid insecticides, which are widely used and highly toxic to honey bees, have been found in previous analyses of honey bee pollen and comb material. However, the routes of exposure have remained largely undefined. We used LC/MS-MS to analyze samples of honey bees, pollen stored in the hive and several potential exposure routes associated with plantings of neonicotinoid treated maize. Our results demonstrate that bees are exposed to these compounds and several other agricultural pesticides in several ways throughout the foraging period. During spring, extremely high levels of clothianidin and thiamethoxam were found in planter exhaust material produced during the planting of treated maize seed. We also found neonicotinoids in the soil of each field we sampled, including unplanted fields. Plants visited by foraging bees (dandelions) growing near these fields were found to contain neonicotinoids as well. This indicates deposition of neonicotinoids on the flowers, uptake by the root system, or both. Dead bees collected near hive entrances during the spring sampling period were found to contain clothianidin as well, although whether exposure was oral (consuming pollen) or by contact (soil/planter dust) is unclear. We also detected the insecticide clothianidin in pollen collected by bees and stored in the hive. When maize plants in our field reached anthesis, maize pollen from treated seed was found to contain clothianidin and other pesticides; and honey bees in our study readily collected maize pollen. These findings clarify some of the mechanisms by which honey bees may be exposed to agricultural pesticides throughout the growing season. These results have implications for a wide range of large-scale annual cropping systems that utilize neonicotinoid seed treatments. Other Sections▼
On 4 April 2012 I revisited the Frontier Medical Institute (also known as the Grossman Wellness Center) in Denver for an update to the comprehensive physical analysis done six years ago. In 2005, my physical system tested at age 45 (when I was chronologically 64). In 2012 my physical system tested at 43 (when my chronological age was 70). My goal was to get a 30 year spread using frequency medicine. I only achieve 27 and hope to do better next time.
The good news is that I anti-aged eight years, i.e. as I got six years older, I physically tested eight years younger.
There are some fascinating new technologies that I experienced and I recommend everyone try out Dr. Grossman's clinic. Even if you can't get there, you can read his new book, Transcend, and get some pointers.
In 2006, several people requested an update on my visit to the Frontier Medical Institute (also known as the Grossman Wellness Center) in Denver, home of the longevity medicine described in the book Fantastic Voyage by Kurzweil and Grossman.
Ray Kurzweil, a recipient of the National Medal of Technology and an inductee into the Inventors Hall of Fame, is one of the world's leading inventors, thinkers, and futurists and the author of three previous books on technology. Terry Grossman M.D., the founder and medical director of the Frontier Medical Institute in Denver, Colorado, a leading longevity clinic, is certified in anti-aging medicine and lectures internationally on matters related to longevity and anti-aging strategies.
During the two days, I spent a lot of time with Dr. Grossman discussing next generation medicine while they took over two pints of blood for analysis, ran me on a treadmill, gave me two rounds of IV chelation therapy, met with a nutritionist and expert in Chinese medicine, used computerized simulators to interact with my physical system and determine my biological age, did a CAT scan of my heart, and finished off with a two hour life coaching session. I'm still sending urine and saliva samples for analysis and all results will not be in for a few weeks.
Here is a preview of the results. My biological age is 24 years younger than my physical age on the average and my heart is 27 years younger than my physical age. The main reason for the lower average is the loss of some high frequencies in my hearing.
The answer to physicians and other people concerning the utility of nutritional supplements is that the proof is in the pudding. If anyone tells you that you don't need nutritional supplements, ask them if they can provide proof that their biological age is at least 20 years less than their physical age. If they don't know, you might recommend Dr. Grossman's program to them.
In the 1980's, it became clear that you could extend your life by 20 years through nutritional supplementation. At the time Ray Kurzweil wrote the book, his physical age was 56 and his biological age was 40 (see page 140). My understanding is that he is pushing a 25 year difference now with an intensive supplementation regime. The upper limit that Dr. Grossman sees is 25 years.
We both agreed that electromagnetic frequencies could push the difference higher and my immediate goal is to achieve a 30 year difference taking far fewer nutritional supplements than Ray Kurzweil. The electronic medicine strategy is beyond what is currently in their book.
I strongly recommend the Frontier Medical Institute program for anyone. If you follow their recommendations it should, conservatively, give you at least 10 more years of quality life. It's not inexpensive. However, if one year of quality life is worth more than a few hundred dollars to you, it is in your financial interest to go through their workup. I view the work they do as the future of medicine. Unfortunately, you won't find it at your local hospital or clinic and the health insurance companies won't pay for most of it.