30 October 2011


Going into hospital far riskier than flying: WHO

A surgeon washes his hands before enter in an operating room at a hospital in Marseille, France, April 3, 2008. REUTERS/Jean-Paul Pelissier
GENEVA | Thu Jul 21, 2011 2:23pm EDT
(Reuters) - Millions of people die each year from medical errors and infections linked to health care and going into hospital is far riskier than flying, the World Health Organization said on Thursday.
"If you were admitted to hospital tomorrow in any country... your chances of being subjected to an error in your care would be something like 1 in 10. Your chances of dying due to an error in health care would be 1 in 300," Liam Donaldson, the WHO's newly appointed envoy for patient safety, told a news briefing.
This compared with a risk of dying in an air crash of about 1 in 10 million passengers, according to Donaldson, formerly England's chief medical officer.
"It shows that health care generally worldwide still has a long way to go," he said.
Hundreds of millions of people suffer infections linked to health care each year. Patients should ask questions and be part of decision-making in hospitals, which must use basic hygiene standards and WHO's checklist to ensure safe surgical procedures were followed.
More than 50 percent of acquired infections can be prevented if health care workers clean their hands with soap and water or an alcohol-based handrub before treating patients.
Of every 100 hospitalized patients at any given time, 7 in developed and 10 in developing countries will acquire at least one health care-associated infection, according to the United Nations agency.
"The longer patients stay in an ICU (intensive care unit), the more at risk they become of acquiring an infection," it said. Medical devices such as urinary catheters and ventilators are associated with high infection rates.
'HIGH-RISK BUSINESS'
Each year in the United States, 1.7 million infections are acquired in hospital, leading to 100,000 deaths, a far higher rate than in Europe where 4.5 million infections cause 37,000 deaths, according to WHO.

28 October 2011

Cancer Cell Glucose Metabolism Version 1.1

Deeper understanding of cell metabolism in cancer can result in innovation frequency strategies for eliminating altered cells. Frequency data are provided to Frequency Foundation subscribers in a private blog that regularly updates frequency sets for researchers. The cancer cell metabolism program is a good indicator of abnormal cells. A positive muscle test when running this program indicates premalignant or malignant cells.

Altered metabolism in cancer
Jason W Locasale and Lewis C Cantley

Locasale and Cantley BMC Biology 2010, 8:88
http://www.biomedcentral.com/1741-7007/8/88
See also research article: http://www.biomedcentral.com/1752-0509/4/58/

Abstract
Cancer cells have different metabolic requirements from their normal counterparts. Understanding the consequences of this differential metabolism requires a detailed understanding of glucose metabolism and its relation to energy production in cancer cells. A recent study in BMC Systems Biology by Vasquez et al. developed a mathematical model to assess some features of this altered metabolism. Here, we take a broader look at the regulation of energy metabolism in cancer cells, considering their anabolic as well as catabolic needs.

Cancer is a disease of uncontrolled cell growth in which cells acquire genetic alterations that allow them to proliferate outside the context of normal tissue development. In the evolution of this transformation, cells acquire mutations that confer selective advantages for the growth of the tumor. Genetic alterations in many of the known oncogenes are selected to adapt cellular metabolism to meet the requirements of rapid cell proliferation as well as autonomous growth and survival in an environment absent of contact with extracellular matrix. Accumulating evidence indicates that almost every known oncogene regulates downstream targets that are directly connected to metabolic regulation. A detailed biochemical and systems-level understanding of precisely how oncogenes rewire metabolism is essential to understand tumor biology, but concomitantly requires an assessment of the metabolic adaptations required to support the proliferation of cancer cells. Understanding the consequences of this differential metabolism requires a thorough analysis of glucose metabolism and its relation to energy production in cancer cells.

In a majority of tumor types, an enhanced rate of glucose uptake is observed and serves as a reasonable starting point for understanding differential metabolism in tumors. Otto Warburg’s initial observation that tumors often metabolize relatively large quantities of glucose predominantly through a fermentative-like metabolism, resulting in lactate production in aerobic conditions (termed aerobic glycolysis), provided the phenomenological foundation for studying altered metabolism in cancer [2]. Rapid progress is being made towards a molecular understanding of why lactate production from glucose gives cancer cells a growth advantage. Paradoxically, cells that achieve high rates of aerobic glycolysis often show relatively small changes in the rate of oxygen consumption in response to changes in glucose uptake; that is, oxidative catabolic flux through the Krebs cycle leading to mitochondrial ATP generation is somewhat independent of glucose metabolism.

26 October 2011

Sleeping Sickness Frequencies 1.0


Tsetse fly photo from microbewiki.
MicrobiologyBytes.com reports:
More than 66 million women, men and children in 36 countries of sub-Saharan Africa suffer from human African trypanosomiasis (HAT). There are two forms of African sleeping sickness, caused by two different parasites:
  • Trypanosoma brucei gambiense , which causes a chronic infection lasting years and affecting countries of western and central Africa 
  • Trypanosoma brucei rhodesiense , which causes acute illness lasting several weeks in countries of eastern and southern Africa 
When untreated, trypanosomiasis gives no respite from suffering and ultimately ends in death. The parasite that causes sleeping sickness is called the trypanosome. It is transmitted to humans through the bite of a tsetse fly; of the genusGlossina.
Human trypanosomiasis is therefore a vector-borne parasitic disease. The vector is found only in Africa, between the fifteenth parallels north and south. Its favoured habitat is the vegetation along watercourses and lakes, forest edges and gallery forests, extending to vast areas of scrub savanna. The tsetse fly feeds on the blood of animals and humans. Once inoculated by an infected fly, the trypanosomes proliferate and gradually invade all the organs of the host.

Most of the parasites are effectively destroyed by the host's natural defences, but some trypanosomes manage to evade the immune system by modifying their surface membrane, a process known as antigenic variation. The trypanosome can express thousands of variants, multiplying with each new surface change.At first, the main clinical signs of human trypanosomiasis are high fever, weakness and headache, joint pains and pruritus (itching). Gradually, the immune defence mechanisms and the patient's resistance are exhausted.

As the parasite develops in the lymph and blood of the patient, the initial symptoms become more pronounced and other manifestations such as anaemia, cardiovascular and endocrine disorders, abortion, oedema and kidney disorders appear. In advanced stages of disease, the parasite invades the central nervous system. The patient's behaviour changes; they can no longer concentrate and become indifferent to their environment. Sudden and unpredictable mood changes become increasingly frequent, giving rise to lethargy with bouts of aggressiveness. Patients are overcome by such extreme torpor that eating, speaking, walking or even opening the eyes call for an unsurmountable effort. At night they suffer insomnia and during the day are exhausted by periods of sleep-like unconsciousness. Finally, patients fall into a deep coma and die.
__________
Frequency Foundation has discovered low grade trypanosomiasis infections in the U.S. and Europe. Subscribers have access to frequencies for multiple strains of the parasite and for the wiggleworthia bacterium spread by the tsetse fly and should test themselves for the presence of these organisms.

25 October 2011

Antidepressants increase risk of autistic children


The study is the first to look at the association between the use of antidepressants during pregnancy and the risk of autism.
The study is the first to look at the association between the use of antidepressants during pregnancy and the risk of autism.
STORY HIGHLIGHTS
  • The study doesn't prove taking SSRIs during pregnancy directly causes autism
  • The findings will need to be confirmed in future studies
  • Women should not be dissuaded from starting or continuing to take SSRIs
  • Untreated depression during pregnancy has its own risks, such as preterm birth
(Health.com) -- Children whose mothers take Zoloft, Prozac, or similar antidepressants during pregnancy are twice as likely as other children to have a diagnosis of autism or a related disorder, according to a small new study, the first to examine the relationship between antidepressants and autism risk.
This class of antidepressants, known as selective serotonin reuptake inhibitors (SSRIs), may be especially risky early on in a pregnancy, the study suggests. Children who were exposed to the drugs during the first trimester were nearly four times as likely to develop an autism spectrum disorder (ASD) compared with unexposed children, according to the study, which appears in the Archives of General Psychiatry.

17 October 2011

If Protecting Health is Not Enough Maybe Saving Money Will Do It!


Looking to Save Money, More Places Decide to Stop Fluoridating the Water

MIAMI — A growing number of communities are choosing to stop adding fluoride to their water systems, even though the federal government and federal health officials maintain their full support for a measure they say provides a 25 percent reduction in tooth decay nationwide.
Last week, Pinellas County, on Florida’s west coast, voted to stop adding fluoride to its public water supply after starting the program seven years ago. The county joins about 200 jurisdictions from Georgia to Alaska that have chosen to end the practice in the last four years, motivated both by tight budgets and by skepticism about its benefits.
Eleven small cities or towns have opted out of fluoridating their water this year, including Fairbanks, Alaska, which acted after much deliberation and a comprehensive evaluation by a panel of scientists, doctors and dentists. The panel concluded that in Fairbanks, which has relatively high concentrations of naturally occurring fluoride, the extra dose no longer provided the help it once did and may, in fact, be harmful.
It is a view that also was shared by four out of seven commissioners in Pinellas County who first raised the proposal as a cost cutting measure.
“I’m in opposition to putting a medical treatment into the public drinking water supply without a vote of the people who drink that water,” said Norm Roche, a newly elected Republican county commissioner who spent 10 years doing policy research for the county Water Department and who led the turnaround effort. “We had a dozen to 15 doctors, dentists, dental hygienists and chemists here who want us to continue this practice but who could not agree themselves on how best to use fluoride.”
Some 700,000 people — 75 percent of the county — will be affected by the vote. The rest receive water from a different source. Read full story ...

09 October 2011

Swine Flu Vaccine Causes Narcolepsy


Finland vows care for narcolepsy kids who had swine flu shot
HELSINKI — The Finnish government and major insurance companies announced Wednesday they will pay for lifetime medical care for children diagnosed with narcolepsy after receiving the swine flu vaccine.
"The compensation will provide much-needed financial assistance for the families, although it cannot take away the emotional distress caused by this condition," Social Services and Health Minister Paula Risikko said in a statement.
Finnish and international researchers recently found a conclusive link between the Pandemrix swine flu vaccine and new cases of narcolepsy, a chronic nervous system disorder which causes people to often uncontrollably fall asleep.
The Finnish Pharmaceutical Insurance Pool (LVP), which represents insurance companies, said Wednesday it would honour all insurance claims in this category.
LVP said it would review each claim individually to calculate the scope of the payout.
The Finnish government meanwhile agreed to cover any medical costs exceeding the insurance claims.
In Finland, 79 children between the ages of four and 19 developed narcolepsy after receiving the Pandemrix vaccine in 2009 and 2010.
Of these cases, an unusually high number, 76, also suffered from bouts of cataplexy, suffering hallucinations or paralysing physical collapses, according to Finnish research.

02 October 2011

Don't Drink the Water

There is more and more political action against flouride in the water. Flouride is a carcinogen that damages brain function even in small doses. View an interesting new video on an actual visit to a water treatment plant in Austin, Texas.
When I was an NCI Principal Investigator of cancer research grants at the University of Colorado School of Medicine in the early 1980's, I often found myself in meetings with the leading researchers in carcinogenesis from all over the world. They advised me not to drink tap water because of the various carcinogens that were always present. Some of them are put in the water intentionally, like flouride.
Fluoride Spurs Bone Cancer Risks in Young Boys The 60th anniversary of fluoridation in the United States (jointly announced by the Centers for Disease Control and the American Dental Association) is certainly nothing to be excited about... A study from the Harvard School of Dental Health found that young boys exposed to fluoridated tap water from ages 5-10 suffered an increased risk of osteosarcoma--bone cancer--between the ages of 10 and 19. This study is the first to link the toxic effects of fluoride to a child's development and the beginnings of bone cancer. (No such link, however, was found among young girls.) Moreover, osteosarcoma, though rare, is an especially dangerous form of childhood cancer, as:
  • The mortality rate in the first five years is about 50 percent.
  • Nearly all survivors have limbs, usually legs, amputated.
  • There are plenty of other things to worry about with a toxic substance like flouride (see Dr. Mercola's links). Frequencies can be transmitted to vibrate flouride atoms and cause them to be flushed from your body. If you have a means to test for frequencies you can determine your level of flouride contamination.