24 September 2005

Increasing Energy 1000% with LifeWave Patches

The LifeWave patches are put on the meridians of the body and affect the electromagnetic field, increasing energy level and burning fat. The photo below shows a white patch on the left shoulder and a tan patch on the right shoulder. This will increase the energy level of the body by about 300%. This translates into a physical capability. If you can do 8 repetitions of lifting weights then will the patches you should be able to do 12. Increasing the energy level by 300% translates into a 30-50% greater capacity for lifting weights.

It also translates into better endurance for long driving trips or leading day long seminars on your feet. At the end of the trip or end of the day, you feel as energetic as when you started. You also have more energy during the trip or the day.

A Qi Gong master recently published a book on how to ramp the energy level up signficantly higher. If you put a white patch on each shoulder and put a two tan patches on each leg meridian just below the knee slightly to the outside, you will increase your energy level by 1000%. This has to be experienced to be believed. Peter Ragnar's 8 repetitions went to 20. My energy level leading seminars is so intense, I seem to have more energy at the end of the day than when I started.

You can get some patches at my LifeWave site. Highly recommended.

LifeWave patches passively interact with the electromagnetic field of the body to increase energy production and burn more calories. Nothing enters the body. Sounds too good to be true, yet Olympic coaches and athletes are using these patches to enhance performance. How do they work?

By David Schmidt, President, LifeWave™ Products, LLC

  • LifeWave™ is a new technology that consists of orthomolecularorganic structures that passively interact with the human body for the purpose of inducing electron flow and thermomagnetic frequency modulation.
  • The induced electron flow assists in recruiting calcium ions into the muscle fiber during the contraction phase, allowing the user to utilize more muscle fiber during contraction, thereby allowing theLifeWave™ user to lift heavier weights.
  • The passive thermomagnetic frequency modulation of the LifeWave™ technology creates a condition in which the transport of long chain fatty acids across the Mitochondrial membrane for subsequent beta-oxidation and energy production is increased, providing theLifeWave™ user with increased energy and stamina.
  • In third party tests conducted independently, over 99% ofLifeWave™ users experienced significant improvements in physical strength after a few minutes of using LifeWave™, with typical increases being 10% and higher.
  • In third party tests conducted independently, over 99% ofLifeWave™ users experienced significant increases in stamina after a few minutes of using LifeWave™, with typical increases being 25% and higher.
  • All materials in LifeWave™ have been clinically tested for safety and efficacy, and are listed under FDA 21 CFR.
  • All LifeWave™ devices are manufactured at FDA registered facilities.
  • Patent Pending

18 September 2005

Legal Brief: American Dental Association Gets Brought to Justice

ADA Gets "Kiss of Death"...
Opinion by Consumer Advocate Tim Bolen
Sunday, September 18th, 2005

It had to happen sooner or later. The ADA (American Dental Association) has had a long run - with the posse chasing them. I'm surprised they've lasted this long.

They'll scream, they'll holler, they'll whine, they'll whimper. They'll threaten, and they'll lash out - but in the end it won't matter - the American Dental Association is finished. Nail their doors shut. Board up their windows. It's soon to be all over for them.

The ADA, as we know in the Health Freedom Movement, stateside, is an organization designed to protect the status quo in US dentistry. Never mind that the methods they protect are from two centuries ago.

We also know that a significant part of the ADA's annual income comes from "product endorsement" (about 42%), and I have a strong feeling that to encourage that "endorsement," the ADA uses its contact with State Dental Boards, to prosecute Dentists that use products NOT endorsed - leaving a distinctive chill on the market.

I can't help but wonder if this type of operation were being performed, say, in the Bronx against "mom & pop" small businesses, it'd be run, by guys named "Big Louie, Hatchet Face, Stabbin' Jack, Dirty Guido, Johnny Leg-Breaker, and Don Alfresco," and the Feds would be wiretapping corner phone booths.

Isn't this called a "protection racket?"

Keep in mind that some of the things they protect, and get income from, include mercury amalgams, flouride in water, and root canals.

But that little bit, above, is just window dressing for the incredible story I'm about to tell you. Sit up, because if you don't - in a minute you're going to spill your health drink all over your freshly washed hemp shirt.


There's six important Court actions ongoing in the United States (US), all involving the US dental establishment, that cumulatively represent the end of the "status quo" in dentistry, and all that it has protected. As we already know, US dentistry lags far behind the rest of the world, with US dentists acting more like automobile body shops than health professionals - focusing on appearance over health.

The first important Court action is in Tennessee. It's a lawsuit called "Barnes v. Kerr," and it is an unusual case. In it, Barnes, a dentist, sued Kerr-McGee, a manufacturer of mercury amalgam for, as DAMS leader Leo Cashman says:

Barnes, who used mercury amalgam fillings for the first ten years of his practice, alleged that he had been poisoned by the mercury in the amalgam fillings that he placed and removed on a daily basis. In 1999, Dr Barnes brought a products liability case against Kerr Corporation, the manufacturer of the only amalgam products Barnes ever purchased. Barnes retained Jim Love and Robert Reeves, attorneys most knowledgeable about mercury amalgams, to represent him. Dr. Mark Richardson, PhD, F.L. Lorscheider, Ph.D., Gary Ordog, M.D., Robert Granacher, M.D., George Colpitts, D.D.S., and other expert witnesses testified on Dr. Barnes’s behalf concerning the various scientific, medical, and dental issues that arose in the case. Kerr challenged the admissibility of Dr. Barnes’s scientific and medical testimony on the basis that it was not supported by valid and reliable published science. However, the trial court ruled that the supporting science was valid and reliable and overruled Kerr’s motion.

Kerr filed an ensuing motion for summary judgment claiming that its warnings were adequate as a matter of law. Kerr also argued that the vast majority of Barnes’s exposure was not attributable to Kerr’s products, but to amalgam fillings that Barnes removed. Because the appearance of an amalgam filling will not reveal the filling’s manufacturer, Kerr argued that Barnes could not prove that Kerr’s products actually injured Barnes. The District Court granted Kerr’s motion. The judgment was appealed to the 6th Circuit U.S. Court of Appeals, but on August 11th, 2005, the Court of Appeals upheld the District Court’s ruling.

If the Sixth Circuit Court’s opinion is published, Barnes v. Kerr may profoundly change the legal landscape regarding amalgam. Barnes argued that Kerr’s warnings addressed only mercury—not mixed dental amalgam. Barnes admitted that he was aware of mercury’s toxicity, but testified that in dental school, he was taught that mixed dental amalgam was safe and the mercury rendered inert. However, the Sixth Circuit’s opinion held that the warning sufficiently notified Barnes that mixed dental amalgam was dangerous. The Court noted, “the label on each jar of dental amalgam capsules featured not only a skull and crossbones next to the word “Poison,” but also a list of illnesses, including “bronchiiolitis, pneumonitis, pulmonary edema [and] redness and irritation to [the] eyes and skin.” Likewise, the Court noted, the MSDS (material safety data sheet, provided to all dentist buyers) warned that chronic mercury exposure could lead to “nervous irritability, weakness, tremors, gingivitis, erethism and graying of the lens of the eye.” Further, the Court ruled that the other ingredients mixed in amalgam with the mercury – silver, copper and tin – are not claimed by the manufacturer to “neutralize the danger while the dentist is working with the product...”

What's important is the following:

1) Under the “learned intermediary” doctrine, dentists are obligated to pass along manufacturer’s warnings to their patients. In light of the ruling in Barnes v. Kerr, dentists will be required to explain to their patients the dangers acknowledged in Kerr’s warnings.

2) Arguably, state dental boards will no longer be able to prohibit dentists from communicating the dangers of mercury amalgam to their patients.

3) In order for a dentist to obtain a patient’s informed consent, the information given to a patient concerning amalgam will change very dramatically.

4) The Court’s opinion will provide a direct challenge to the ADA’s proclamations of amalgam safety.

5) In formulating a successful legal strategy, Kerr may have impaired the market for its dental amalgam product.

The second important case is in Ohio. It's called "Kerger v. ADA, et al." In this case, a woman, Jessica Kerger, sued the ADA, The Ohio Dental Association, and two mercury amalgam manufacturers, for, as Leo Cashman says:

A personal injury lawsuit against them by Jessica Kerger, an Ohio woman, and her family is gaining traction in the courtroom. Judge Nancy A. Fuerst has denied a detailed “motion to dismiss” by the defendants, two dental amalgam manufacturers, the American Dental Association (ADA) and the Ohio Dental Association (ODA). In her complaint, Jessica Kerger alleges that she has suffered neurological deficits and hormonal function problems relating to mercury from her dental amalgam fillings. In 2004, Kerger sued amalgam makers and the ADA and ODA for personal injuries resulting in serious disability. Some parts of the Kerger complaint were dismissed by the court, but key claims were not dismissed, including “fraud, misrepresentation and negligent claims to a third party.”

“The stuff that really matters stayed in,” Jessica Kerger said. The ADA has petitioned Judge Fuerst to clarify her ruling and say why she kept the key charges in court.

Normally, in a case like this (Kerger) I'd shrug my shoulders and "wait and see," for I know that the ADA will trot out all of it's usual arguments. Like the tobacco industry, the ADA has been defending these things for years - and knows how to proceed. Which brings us to the third case...

The third important Court action is in Illinois - and it is related to the Kerger case. It's called "Federal Insurance v. ADA," and it's "the kiss of death," no matter how it's decided, for the ADA. For, Federal Insurance was the ADA's insurance carrier during the time Jessica Kerger was being injured. They are no longer their insurer.

Federal Insurance, a division of the CHUBB group, is as Leo Cashman says:

Meanwhile another court will have to determine whether the ADA has any insurance coverage in the Kerger case. The ADA’s former insurer, Federal Insurance Company, has sued the ADA charging that any ADA conduct that would have hurt Jessica Kerger (e.g., caused her to mercury poisoned by dental amalgams) was deliberate and intentional and therefore not covered by its insurance policies with Federal (Federal Insurance provided insurance coverage for ADA from 1965 until January 1, 2000)… The ADA has been the industry’s biggest defender of the dental amalgam (mercury) filling, even going so far as to hold that it is “unethical” for a dentist to replace an amalgam filling out of concern for the toxicity of mercury. It has also obtained revenue for giving its Seal of Approval for the amalgam product sold by the various dental material manufacturers. Without Federal Insurance by its side, ADA would have to be on its own for its defense in the Jessica Kerger case and would be on its own to absorb potentially huge liability lawsuit damages in the Kerger case and others like it.

Federal Insurance Company, established in 1901, is a division of the Chubb Group of Insurance Companies, one of the world’s top global insurance companies. Chubb has over 100 offices, in 30 countries. Even by itself, Federal itself has over $23 billion in assets and a net worth close to $8 billion. If it is now taking an adversarial role towards the ADA and its conduct regarding amalgam, it appears to have the lawyers and the deep pockets to press its case.

The fourth important case is in Colorado - and I've spoken about it many times. It's called the "Cavitat v. Aetna" Federal Lawsuit, which, is by the way, proceeding along nicely. Aetna countersued Cavitat a while back, claiming a whole host of strange things. In it they called me a "Paid Troublemaker," among other things, and for some reason, every time I read their claim (which, I admit, isn't often), I have to laugh - even Aetna has problem finding good attorneys, I guess, but there's a Motion for Dismissal in front of the Judge - so we'll see what happens.

From reading the Court documents available through the Pacer system on the Cavitat case, it looks as though Aetna's BIG MOVE is to hide the transcript, from the public, of Robert S. Baratz MD, DDS, PhD's ("Bobbie Bogus") deposition in this case.. For what-ever reason, Aetna seems to want that information withheld. Knowing Baratz, and the way he testifies when he's under fire, his testimony was probably so damning, Aetna's CEO has probably already written Cavitat a check - they just haven't delivered it yet... For the most part Aetna relied on Baratz's statements to attack Cavitat - and that's why Cavitat sued them.

Baratz, you may remember, made history in a Wisconsin hearing room, a few years ago - when he sweat through his suit while being examined in a three day "credibility hearing," I helped organize. He also, in Florida, before that, came running into a hearing room shrieking like a girl, claiming "My life is in danger. I need police protection, blah-blah-blah, squeak, squeak, squeak..." just because I was in the building. Then there was that hearing in Boston last June where I showed up...

I FULLY understand why Aetna would want to suppress what Baratz says. That is EXACTLY the right thing to do. BUT, Aetna is more than a little late. They should have suppressed what Baratz, and his "quackbuster" cronies, said about Cavitat BEFORE they put all that crap on their website - the stuff they got sued for.

Now It's time for Aetna to write a check - or face a Colorado jury, bringing shrieking, sweaty, Bobbie in as their witness. (Insert laughter here). They won't be able to hide this clown from the jury... Baratz is the best witness Cavitat has - and supposedly, he's Aetna's witness...

The fifth important case is in Massachusetts - and I've spoken about it only once before. It was the June 6th hearing in Boston story and the case surrounding it. This'll be the very first time that anyone has outright challenged the use of a quackbuster, like little Bobbie Baratz, as the primary, or only, witness, in a dental case. This case challenges the "ultimate" authority of the ADA. Simply put, so far, several State of Massachusetts employees have been sued for using a known crackpot dirtbag like Bobbie Baratz, and who he represents, as a witness against a reputable dentist. I'll let you know what happens.

But here's a little tidbit to think about - the State of Massachusetts did little, if any, checking on Bobbie's veracity, or his so-called expertise. For instance, Bobbie testified for about six and a half hours about how this dentist improperly installed a dental bridge in a patient's mouth. On cross-examination Baratz was forced to admit that since 1986 (where in another case he claimed he "no longer practiced dentistry") he had not installed any bridges. In fact, he has NEVER, EVER, installed a bridge. When asked about how he felt he could testify "as an expert" on a subject he knew NOTHING about, he replied "I researched it..."

Personally, I do not understand why Baratz has survived as a so-called "expert witness" this long. Anyone, and everyone, who uses him should be sued for all that they may own.

The sixth important case is in Wisconsin - and I've spoken about it many times. It's the Vander Heyden case. This a case where the dental establishment simply wanted to flex its muscles. They were going to show the upstart "Biological Dentists" just who had the biggest horns in the pasture. So, without the benefit of the law on their side, or expertise, or much of anything, including a prosecutor who clearly didn't even know how to organize a case, they charged Rick Vander Heyden with "practicing beyond the scope of Dentistry," because he once used an electronic device, along with regular diagnostic tools, to help him try and figure out just what was causing a patient a particular problem.

Well, the prosecutor didn't even bring a witness into the Courtroom at all - none - and certainly no expert witnesses. But that didn't deter the actual Dental Board from taking Rick's license away from him. They did. Naturally, it went to Court, and a few days ago, as I expected, the Court reversed the Board's ruling, staying the revocation - and scheduled a hearing. My feeling - the prosecutor didn't put on a case in front of the Administrative Law Judge because he already had a "Decision" from key Dental Board members in his pocket.. Vander Heyden was targeted. Now, of course, things have changed.

14 September 2005

Surgery May Unleash Breast Cancer Growth

Wednesday, September 14, 2005

By Daniel J. DeNoon

Can removing a breast cancer cause rapid growth of tumors elsewhere in the body?

Yes, according to indirect evidence from a new analysis of clinical trial data. The controversial theory comes from Michael Retsky, PhD, of Children’s Hospital/Harvard Medical School in Boston, and colleagues.

"We say this is indirect evidence; we think this is a key to understanding the biology of breast cancer," Retsky tells WebMD. "We certainly do not suggest any changes in clinical practice based on this. We hope this will entice clinical and experimental people to test these hypotheses."

However, the theory is extremely controversial. A spokesman for the American Cancer Society says the findings are based on a misreading of existing data.

Big Tumors Fighting Little Tumors

Retsky and colleagues looked at long-term data on breast cancer patients treated in Italy. They saw two peaks in breast cancer relapse among premenopausal women whose cancer had spread to their lymph nodes. One relapse peak came very early -- just 18 months after cancer diagnosis. The other started nearly five years after diagnosis.

This led them to a hypothesis. Cancers that relapse five or more years after cancer surgery, they suggest, come from single cancer cells in the body that grow slowly over time. Early relapses, they suggest, come from tiny, dormant cancers about 1 millimeter in size.

What makes these tiny cancers grow?

Animal studies show that big tumors give off chemical signals that keep smaller cancers from growing. When these big tumors are removed, the smaller cancers quickly grow blood vessels and become deadly.

The same thing may happen in some women after breast cancer surgery, Retsky says. And it's seen only in younger women, he suggests, because reproductive hormones boost the cancer-enhancing effect.

Breast Cancer Screening Paradox

For more evidence, Retsky's team looked at what some call the breast cancer screening paradox. It comes from observations in clinical trials comparing regular mammogram screening with no screening. In the first few years, women in their 40s who have mammograms -- but not those in their 50s -- have a higher risk of death than those not offered screening.

Over time, breast cancer screening shows a benefit for all women. But why the early increase in risk? Could it be due to women with node-positive breast cancer who suffer early relapses after surgery? Retsky suggests that it is.

Looking at data from studies of breast cancer screening, Retsky and colleagues saw about one excess death per 10,000 screened young women in the third year of screening. That, he says, is just what one would expect if his hypothesis is correct.

"It looked like surgery accelerated the disease by two years on average, which is the usual dormancy of this [blood vessel-free] tumor state," Retsky says. "All the data show this."

Even so, Retsky stresses, younger women with breast cancer still need surgery. He strongly advises women to continue to seek breast cancer screening -- and, when a cancer is found, to have it removed.

"We don't have all the answers," Retsky says. "We think our work has pointed out that the mammography paradox is real. We are confident we understand what causes it. We have identified a problem -- a mechanism that is testable. We have not found a solution. But identifying the problem is a major step in the right direction."

Retsky and colleagues report their findings in the current issue of the International Journal of Surgery.

American Cancer Society Says It Isn't So

Don't believe any of this, says Robert A. Smith, PhD, director of cancer screening for the American Cancer Society.

"The data don't add up to Dr. Retsky's conclusion," Smith tells WebMD. "The idea that surgical interruption of the tumor bed will cause death this rapidly just does not make sense."

Smith, a strong proponent of early and regular breast cancer screening, says the apparent screening paradox does not exist.

"You do not expect mammograms to be instantly beneficial," he says. "When you first invite women to screening, you get some with tumors that are already advanced. And not all of the women will respond to the invitation to screening. They may die next year or the year after, and because they were invited, they will be counted as a death in the screening group. So you really can't look at this pattern and make any sense out of it."

Young women, Smith says, tend to get more aggressive breast cancers.

"So the idea these women became worse after surgery may stem from the fact that their prognosis may have been poorer to begin with," he says.

And Smith notes that Retsky's data are based on observations from long ago, when breast cancer screening was in its infancy.

"The interesting thing is how beneficial modern, high-quality mammography can be," he says. "Mammograms are quite a bit better today than in the clinical trials that proved they saved lives."

By Daniel J. DeNoon, reviewed by Michael W. Smith, MD

SOURCES: Retsky, M.W. International Journal of Surgery, published online, Sept. 12, 2005. Michael Retsky, PhD, Children’s Hospital/Harvard Medical School, Boston. Robert A. Smith, PhD, director of cancer screening, American Cancer Society.

09 September 2005

British Medical Journal Perspective on Katrina

The kindness of strangers

On the fourth anniversary of 9/11, Americans find themselves once again counting the cost of an unimaginable catastrophe. This time though, the world has looked on not in awe at the human spirit arising from the ashes of the Twin Towers, but in shock and shame at the sight of the world's richest country doing so little so late for its poorest people. The fallout from Hurricane Katrina will be weighed in thousands of lives lost and many more thousands wrecked (pp 526, 531, 582), and in further damage to America's reputation around the world.

When the US government finally accepted offers of help from the United Nations last week, secretary general Kofi Annan might have been forgiven for feeling a certain degree of schadenfreude. This is after all also the UN's 60th anniversary, an opportunity for the UN's critics to crank up pressure to reform. Few would disagree that the UN is inefficient, bureaucratic, and encumbered with an impossibly broad mandate. In this week's BMJ, Kelly Lee calls it "a management consultant's worst nightmare" (p 525). But in the build up to next week's UN summit, US criticism of the UN—embodied in the form of US ambassador, John Bolton—has moved beyond these well worn gripes to questioning key aspects of the UN's strategy. Most significantly, Bolton has called for the removal from next week's agenda of all reference to the millennium development goals (MDGs).

Whatever one's view of the MDGs (seen by some as reflecting the priorities of donors rather than recipient nations and by most people as probably unachievable), they do focus attention in the rich world on the health needs of the poor. Targets give the international community a stick with which to beat itself when it falls short on commitments, as it is clearly doing (p 536).

The US government wants the world's attention to shift elsewhere, but the UN must resist this, whatever threats its largest donor makes to withdraw funding. America's own recent experience shows the dangers of diverting funds from routine public health initiatives to perceived, and probably overestimated, threats to homeland security. Erica Frank estimates that on 11 September 2001, and on every day since then, over 5000 people died in the US from 10 leading causes, including heart disease, cancer, and stroke (p 526). "Predictable tragedies happen every day," she says, but funds are being diverted to prevent bioterrorism, leaving health departments in the US without money for basic disease surveillance. The most recent effects of the diversions of funds can be seen in the disastrous flooding after Hurricane Katrina.

The neglected levees will be repaired, the flood waters will recede, and street cars will again ply their routes to New Orleans' sunken districts of Desire and Cemetery. But how much will America's leaders be willing to learn from their unfamiliar and uncomfortable experience of having had to depend on the kindness of strangers?

Fiona Godlee, editor

07 September 2005

Red Wine Molecule Prevents Plaque From Forming In Arteries Regardless of Cholesterol Count

Reported by www.longevinex.com:

For over a decade researchers have debated whether red wine produces health benefits because of its alcohol content, or because of other molecules in red wine. Now researchers at Nanjing Medical University in China report on the use of de-alcoholized red wine and cardiovascular health. Animals were fed alcohol, red wine, de-alcoholized red wine and pure research-grade resveratrol, a molecule found in red wine. Animals were then fed a high cholesterol diet and the human equivalent of 210 milligrams of resveratrol, or 280 millilters of red wine or alcohol-free red wine.

The results of the study are surprising. After 12 weeks the animals actually experienced a rise in circulating levels of total cholesterol, LDL cholesterol, and "good" HDL cholesterol regardless of whether they were fed alcohol, red wine, alcohol-free red wine or resveratrol.

However, while cholesterol plaque formed in the arteries (thoracic aorta) of the cholesterol-fed animals, the size, density, and mean area of atherosclerotic plaques were significantly reduced in rabbits given de-alcoholized red wine, red wine, or resveratrol. Resveratrol prevents cholesterol plaque from forming within artery wall regardless of whether circulating levels of cholesterol are high or low!

Dealcoholized red wine containing known amounts of resveratrol suppresses atherosclerosis in hypercholesterolemic rabbits without affecting plasma lipid levels.
International Journal Molecular Medicine 16:533-540, 2005
Wang Z, Zou J, Cao K, Hsieh TC, Huang Y, Wu JM.
Department of Cardiology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, P.R. China.

Moderate consumption of red wine is associated with a reduced risk of coronary heart disease (CHD). This phenomenon is based on data from epidemiological observations known as the French paradox, and has been attributed to CHD-protective phytochemicals, e.g. resveratrol in red wine. Since red wine also contains alcohol, it is conceivable that alcohol interacts with resveratrol to elicit the observed cardioprotective effects.

To determine whether resveratrol has alcohol-independent affects, we compared cardioprotective properties of dealcoholized Chinese red wine with alcohol-containing Chinese red wine having comparable amounts of resveratrol, using a hypercholesterolemic rabbit model and resveratrol as a reference. Animals fed a high cholesterol (1.5%) diet were simultaneously given water containing resveratrol (3 mg/kg/day) or red wine (4 ml/kg/day) containing 3.98 mg/l and 3.23 mg/l resveratrol for regular and dealcoholized red wine, respectively, for a 12-week duration. Total, HDL- and LDL-cholesterol and triglyceride levels in the plasma were measured before and after the cholesterol challenge. Atherosclerotic plaques in the thoracic aorta were evaluated using histochemical methods. Vascular and endothelial functions in the femoral artery were also assessed by ultrasonographic image analysis.

High cholesterol-fed animals showed a significant increase in plasma levels of total, HDL- and LDL-cholesterol, but not triglycerides, compared to those fed a regular diet. Dietary cholesterol-elicited lipid changes were similarly observed in animals concurrently fed dealcoholized red wine, red wine or resveratrol. In contrast, whereas atherosclerotic lesions were clearly evident in specimens prepared from the thoracic aorta of high cholesterol-fed animals, the size, density, and mean area of atherosclerotic plaques, and thickness of the intima layer were significantly reduced in rabbits given dealcoholized red wine, red wine, or resveratrol.

These results were in agreement with data obtained by an ultrasound analysis of endothelial function, which showed a 25% reduction in flow-mediated dilation (FMD) in rabbits fed a high cholesterol diet compared to animals on control diet. This decrease was effectively prevented by the simultaneous exposure to dealcoholized red wine, red wine, or resveratrol. Our study shows that animals given dealcoholized red wine exhibited cardio-active effects comparable to those of animals orally administered resveratrol, and suggests that wine polyphenolics, rather than alcohol present in red wine, suffice in exerting cardioprotective properties. The results also provide support for the notion that resveratrol and phytochemicals in red wine can suppress atherosclerosis without affecting plasma lipid levels.

05 September 2005

Take Olive Oil Instead of Ibuprofen

Olive oil reveals its hidden virtue
New Scientist, Sep 2005

EXTRA-virgin olive oil has a similar anti-inflammatory effect to ibuprofen. That may help explain why the Mediterranean diet, rich in olive oil, protects against heart disease, cancer and Alzheimer's disease.

Paul Breslin and his team at the Monell Chemical Senses Center in Philadelphia have discovered that olive oil contains the compound oleocanthal which, like ibuprofen, turns out to be a COX-1 and COX-2 inhibitor (Nature, vol 437, p 45). "Structurally it's not similar, but pharmacologically it's very similar," says Breslin.

About 50 millilitres of olive oil a day effectively amounts to a low-dose anti-inflammatory, the researchers say.

04 September 2005

Vitamin E Improves Longevity 40% in Male Mice

Am J Physiol Regul Integr Comp Physiol (July 14, 2005). doi:10.1152/ajpregu.00834.2004

Vitamin E at high doses improves survival, neurological performance and brain mitochondrial function in aging male mice

Ana Navarro1*, Carmen Gomez1, Maria-Jesus Sanchez-Pino1, Hipolito Gonzalez1, Manuel J Bandez1, Alejandro D , and Alberto 2

1 Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, 11003-Cadiz, Spain
2 Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, C1113AAD-Buenos Aires, Argentina
E-mail: ana.navarro@uca.es

Male mice receiving vitamin E (5.0 g alpha-tocopherol acetate/kg of food) from 28 wk of age showed a 40 % increased median lifespan, from 61 ± 4 wk to 85 ± 4 wk, and 17 % increased maximal lifespan, whereas female mice equally supplemented exhibited only 14 % increased median lifespan.

The alpha-tocopherol content of brain and liver was 2.5-times and 7-times increased in male mice, respectively. Vitamin E-supplemented male mice showed a better performance in the tightrope (neuromuscular function) and the T-maze (exploratory activity) tests with improvements of 9-24 % at 52 wk and of 28-45 % at 78 wk. The rates of electron transfer in brain mitochondria, determined as state 3 oxygen uptake and as NADH-cytochrome c reductase and cytochrome oxidase activities, were 16-25 % and 35-38 % diminished at 52-78 wk. These losses of mitochondrial function were ameliorated by vitamin E supplementation by 37-56 % and by 60-66 % at the two considered time points. The activities of mtNOS and Mn-SOD decreased 28-67 % upon aging and these effects were partially (41-68 %) prevented by vitamin E treatment. Liver mitochondrial activities showed similar effects of aging and of vitamin E supplementation, although less marked. Brain mitochondrial enzymatic activities correlated negatively with the mitochondrial content of protein and lipid oxidation products (r2 = 0.58-0.99, p < .01) of respiration and of complex I and IV activities correlated positively (r2 = 0.74-0.80, p < .01) behavioral tests and with maximal lifespan.

01 September 2005

Klotho Protein Extends Mouse Life 20-30%

A 2-month-old mouse deficient in the Klotho protein, center, shows signs of aging, compared with a normal mouse, left. A 3-year-old mouse with an overabundance of the protein, right, has lived beyond the normal life span. (By Aline Mckenzie -- University Of Texas Southwestern Medical Center At Dallas)

Life-Lengthening Hormone Found in Mouse Research
By Rob Stein
Washington Post Staff Writer
Friday, August 26, 2005; Page A01

Scientists have identified a hormone that significantly extends the life span of mice, a discovery that could mark a crucial step toward developing drugs that boost longevity in people.

The hormone is the first substance identified that is produced naturally in mammals, including humans, and can extend life span -- a long-sought goal in the intense effort to help people live longer.

Much more work is needed to study the substance, and investigate whether the hormone or a similar compound would be effective and safe in people, experts cautioned. But the discovery opens highly promising avenues for research and provides tantalizing new clues toward deciphering the basic biology of aging.

"This is a significant discovery. It's an exciting paper," said Anna McCormick of the National Institute on Aging, which helped fund the new research, published online yesterday by the journal Science. "It's definitely the way you would go about designing molecules that would promote healthy aging and longevity in people."

Makoto Kuro-o of the University of Texas's Southwestern Medical Center at Dallas, who led the research, said, "This could provide a key to understanding the molecular mechanisms of aging and opens up new areas to the potential therapy for multiple age-related diseases in humans."

The discovery was triggered by a study Kuro-o and his colleagues published in 1997. That study identified a gene in mice that, when damaged, caused the animals to experience all the hallmarks of aging in humans -- hardening of the arteries, thinning bones, withered skin, weak lungs -- and to die prematurely. They dubbed the gene Klotho, for the Greek goddess who spins the thread of life.

Suspecting the gene may play a role in regulating life span, Kuro-o and his colleagues genetically engineered mice with overactive Klotho genes. In the latest experiments, they found that these animals lived an average of 20 to 30 percent longer than normal -- 2.4 to 2.6 years vs. a normal life span of about two years -- without any signs of ill effects, according to the new report.