28 March 2003

Cell Phones: Electromagnetic Fields Can Cause Genetic Damage

Exposure of human peripheral blood lymphocytes to electromagnetic fields associated with cellular phones leads to chromosomal instability
Maya Mashevich 1 3, Dan Folkman 2, Amit Kesar 2, Alexander Barbul 3, Rafi Korenstein 3 *, Eli Jerby 2, Lydia Avivi 1

continuous RF fields • nonthermal effects • aneuploidy • centromeric DNA replication • carcinogenesis

Whether exposure to radiation emitted from cellular phones poses a health hazard is at the focus of current debate. We have examined whether in vitro exposure of human peripheral blood lymphocytes (PBL) to continuous 830 MHz electromagnetic fields causes losses and gains of chromosomes (aneuploidy), a major somatic mutation leading to genomic instability and thereby to cancer. PBL were irradiated at different average absorption rates (SAR) in the range of 1.6-8.8 W/kg for 72 hr in an exposure system based on a parallel plate resonator at temperatures ranging from 34.5-37.5 °C. The averaged SAR and its distribution in the exposed tissue culture flask were determined by combining measurements and numerical analysis based on a finite element simulation code. A linear increase in chromosome 17 aneuploidy was observed as a function of the SAR value, demonstrating that this radiation has a genotoxic effect. The SAR dependent aneuploidy was accompanied by an abnormal mode of replication of the chromosome 17 region engaged in segregation (repetitive DNA arrays associated with the centromere), suggesting that epigenetic alterations are involved in the SAR dependent genetic toxicity. Control experiments (i.e., without any RF radiation) carried out in the temperature range of 34.5-38.5 °C showed that elevated temperature is not associated with either the genetic or epigenetic alterations observed following RF radiation - the increased levels of aneuploidy and the modification in replication of the centromeric DNA arrays. These findings indicate that the genotoxic effect of the electromagnetic radiation is elicited via a non-thermal pathway. Moreover, the fact that aneuploidy is a phenomenon known to increase the risk for cancer, should be taken into consideration in future evaluation of exposure guidelines. Bioelectromagnetics 24:82-90, 2003. © 2003 Wiley-Liss, Inc.

21 March 2003

HIgher plasma Vitamin C reduces risk of stroke

Linus Pauling emphasized in our discussions years ago that Vitamin C excreted in the urine did not mean you had too much Vitamin C. He argued that maintaining high plasma vitamin C had all sorts of positive effects. Reduction in the risk of stroke is one of them. A couple of glasses of fresh orange juice a day contains enough vitamin C to cut stroke risk in half. Pauling felt that significantly more vitamin C in the bloodstream had far reaching systemic effects.

Plasma Vitamin C Modifies the Association Between Hypertension and Risk of Stroke
S. Kurl, MD; T.P. Tuomainen, MD; J.A. Laukkanen, MD; K. Nyyssönen, PhD; T. Lakka, MD, PhD; J. Sivenius, MD, PhD; J.T. Salonen, MD, PhD, MscPH
Stroke. 2002;33:1568.

Background and Purpose— There are no prospective studies to determine whether plasma vitamin C modifies the risk of stroke among hypertensive and overweight individuals. We sought to examine whether plasma vitamin C modifies the association between overweight and hypertension and the risk of stroke in middle-aged men from eastern Finland.

Methods— We conducted a 10.4-year prospective population-based cohort study of 2419 randomly selected middle-aged men (42 to 60 years) with no history of stroke at baseline examination. A total of 120 men developed a stroke, of which 96 were ischemic and 24 hemorrhagic strokes.

Results— Men with the lowest levels of plasma vitamin C (<28.4 µmol/L, lowest quarter) had a 2.4-fold (95% CI, 1.4 to 4.3; P=0.002) risk of any stroke compared with men with highest levels of plasma vitamin C (>64.96 µmol/L, highest quarter) after adjustment for age and examination months. An additional adjustment for body mass index, systolic blood pressure, smoking, alcohol consumption, serum total cholesterol, diabetes, and exercise-induced myocardial ischemia attenuated the association marginally (relative risk, 2.1; 95% CI, 1.2 to 3.8; P=0.01). Adjustment for prevalent coronary heart disease and atrial fibrillation did not attenuate the association any further. Furthermore, hypertensive men with the lowest vitamin C levels (<28.4 µmol/L) had a 2.6-fold risk (95% CI, 1.52 to 4.48; P<0.001), and overweight men (25 kg/m2) with low plasma vitamin C had a 2.7-fold risk (95% CI, 1.48 to 4.90; P=0.001) for any stroke after adjustment for age, examination months, and other risk factors.

Conclusions— Low plasma vitamin C was associated with increased risk of stroke, especially among hypertensive and overweight men.

15 March 2003

Pharmaceutical Grade Fish Oil: Something Everyone Should Be Taking

Grandma used to give the kids cod liver oil because it helped out the immune system. It tasted bad but it worked. These days, there are a lot of toxins in fish and concentrating the oil must be done by molecular distillation to avoid concentrating the toxins along with the oil.

Before I comment further on fish oil, it is important to note that the best supplement for immune function is Transfer Factor Plus. Research shows that nothing comes close to its effectiveness and I can vouch for it personally as I take it every day. It is the only supplement I have set up a web page for because it is critical that anyone with any chronic disease be supplementing their immune system. You can order it by clicking here, and it is as safe for kids as for adults. For the little ones it will prevent or help recover from colds and flu. For adults, it could save your life.

The next most important supplement to take is pharmaceutical grade fish oil. The best brand is produced by Dr. Sears Labs and is expensive. I take it because it has significant effects on multiple facets of body function. It is particularly good at lowering the heart rate (great for runners) and reducing the risk of heart disease in general. There is an inexpensive Canadian brand of pharmaceutical grade oil sold at www.iherb.com, Rx Omega 3 Factors. Several people have sent me email asking where they can find it, so I am posting the link here.

I have thousands of supplements that I have tested in my laboratory at home and I only take four things regularly: Transfer Factor, pharmaceutical grade fish oil, a really good vitamin supplement, and Horizon Low Fat Cottage Cheese mixed with Barlean's flax seed oil for cancer prevention (the only combination that tastes good). Vitamin supplements need to be commented on separately, as these merit a longer discussion.

Fish consumption and risk of stroke in men.
He K, Rimm EB, Merchant A, Rosner BA, Stampfer MJ, Willett WC, Ascherio A.
JAMA 2002 Dec 25;288(24):3130-6
Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, Mass 02115, USA. khe@hsph.harvard.edu

CONTEXT: The effect of fish consumption or long-chain omega-3 polyunsaturated fatty acid (PUFA) intake on risk of stroke remains uncertain.
OBJECTIVE: To examine the relation of fish consumption and long-chain omega-3 PUFA intake and risk of stroke in men.
DESIGN AND SETTING: The Health Professional Follow-up Study, a US prospective cohort study with 12 years of follow-up.
PARTICIPANTS: A total of 43671 men aged 40 to 75 years who completed a detailed and validated semiquantitative food frequency questionnaire and who were free of cardiovascular disease at baseline in 1986.
MAIN OUTCOME MEASURE: Relative risk (RR) of stroke by subtype based on cumulative average fish consumption or long-chain omega-3 PUFA intake, ascertained in 1986, 1990, and 1994.
RESULTS: We documented 608 strokes during the 12-year follow-up period, including 377 ischemic, 106 hemorrhagic, and 125 unclassified strokes. Compared with men who consumed fish less than once per month, the multivariate RR of ischemic stroke was significantly lower among those who ate fish 1 to 3 times per month (RR, 0.57; 95% confidence interval [CI], 0.35-0.95). However, a higher frequency of fish intake was not associated with further risk reduction; the RR was 0.54 (95% CI, 0.31-0.94) for men who consumed fish 5 or more times per week. This lack of linearity was confirmed by spline analyses. By dichotomized fish intake, the multivariate RR for men who consumed fish at least once per month compared with those who ate fish less than once per month was 0.56 (95% CI, 0.38-0.83) for ischemic stroke and 1.36 (95% CI, 0.48-3.82) for hemorrhagic stroke. The inverse association between fish intake and risk of ischemic stroke was not materially modified by use of aspirin. No significant associations were found between fish or long-chain omega-3 PUFA intake and risk of hemorrhagic stroke.
CONCLUSION: Our findings suggest that eating fish once per month or more can reduce the risk of ischemic stroke in men.

Body Burden: Industrial Pollutants You Are Carrying in Your Body

Bill Moyers was one of the study subjects in a recent study of body burden of industrial pollutants. His blood had over 30 different types of PCBs and a host of other contaminants.

BodyBurden: The Pollution in People

In a study led by Mount Sinai School of Medicine in New York, in collaboration with the Environmental Working Group and Commonweal, researchers at two major laboratories found an average of 91 industrial compounds, pollutants, and other chemicals in the blood and urine of nine volunteers, with a total of 167 chemicals found in the group. Like most of us, the people tested do not work with chemicals on the job and do not live near an industrial facility.

Scientists refer to this contamination as a person’s body burden. Of the 167 chemicals found, 76 cause cancer in humans or animals, 94 are toxic to the brain and nervous system, and 79 cause birth defects or abnormal development. The dangers of exposure to these chemicals in combination has never been studied.

02 March 2003

Nosocomial Infections: Methicillin Resistant Staphylococcus Aureus (MRSA)

Superbug killer found in rockpool
CNN, Thursday, February 27, 2003 Posted: 5:35 AM EST (1035 GMT)
EDINBURGH, Scotland -- Scientists may have found the answer to Britain's most dangerous hospital superbug -- in slime taken from Scottish rock pools.

A reader sent me the superbug CNN article when it was published last Thursday. Medical error is the third leading cause of death in the United State and a major component of that error is nosocomial infections (you get sick because you are in the hospital with bugs you did not have when you entered the hospital). Dr. Starfield, at Johns Hopkins, reports that there are about 80,000 deaths each year from nosocomial infections in the U.S. alone. CNN notes that the staphylococcus bacteria accounts for almost half of all UK hospital infections. In the U.S., MRSA accounts for about 25% of infections, or 20,000 deaths a year. The drug companies are hot on the trail of yet a better antibiotic.

There are so many interesting questions about this bug and avoidance or treatment of antibiotic-resistant infections in general that I will take several postings to comment on even a few items.

1. What is the electronic resonant frequency of MRSA, and can it easily be killed by a frequency generator or Rife machine?
2. Why are nasty bugs like this most prevalent in hospitals?
3. What alternative strategies could we take to avoid evolving nasty, resistant bug strains in the future?
4. What easy nutritional aid could be given to hospital patients that is proven in clinical trials and would drastically reduce the number of infections by this bug. What is the probability of getting this nutritional aid if you go into the hospital? Is failure to provide proven treatments common in medicine today? Is failure to provide this assistance malpractice?
5. Do you have this bug in your system? Should you eliminate it? What could you do if you get it and treatment with antibiotics is futile?