Nativis science and technology is based on magnetically induced electron and charge transfer. Electron transfer is central to the function of many biologic processes and artificial magnetic fields are capable of triggering a receptor response and conformational change in the absence of a physical agonist. A specific and precise oscillating magnetic field with the proper vector, magnitude and pulse duration can move a charge along a protein pathway much the same way an electron is forced to move in copper wire. A charge moving between a donor and acceptor site in the presence of an oscillating magnetic field will result in a conformational dynamic similar to a naturally forced charge.
Non-Thermal Radio Frequency Stimulation of Tubulin Polymerization in Vitro: A Potential Therapy for Cancer Treatment
John T. Butters1, Xavier A. Figueroa2*, Bennett Michael Butters1 1 Nativis Inc., Seattle, WA, USA 2 Sciencia Incognita Consulting, LLC, Seattle, WA, USA
Copyright © 2014 by authors and Scientific Research Publishing Inc. This work is licensed under the Creative Commons Attribution International License (CC BY). http://creativecommons.org/licenses/by/4.0/
Abstract The use of radio frequency energy is an established technology for certain oncology therapies. Direct inputs of radio frequency (RF) energy as thermal energy are applied to ablate tumors or catalyze secondary reactions in adjunct treatments against certain tumor types. Yet, other applications are being developed which take advantage of properties of RFs that impinge on biological proteins and cells without thermal effects. Here we report a proof-of-concept application of specific, digitally encoded, low power (non-thermal) radio frequency energy in an in vitro preparation of a tubulin polymerization assay. The radio frequency energy signal, designated M2(3), was applied to the tubulin polymerization assay samples during spectrophotometric measurements to assess the effectiveness for enhancing tubulin polymerization. A commercially available taxane (paclitaxel) that promotes tubulin polymerization was used as a control to assess the effectiveness of the M2(3) radio frequency energy signal on tubulin polymerization rates. A low power, specific, digital radio frequency energy signal is capable of promoting tubulin polymerization as effectively as a commercially available taxane.